Role of PhoPR in the response to stress of Mycobacterium bovis

PhoP is part of the two-component PhoPR system that regulates expression virulence genes Mycobacteria. The goal this work was to elucidate role in mechanism Mycobacterium bovis, causative agent bovine tuberculosis, displays upon stress. An analysis gene and acidic growth curves indicated M. bovis neutralized external environment by inducing secreting ammonia. We found essential for ammonia production/secretion its process seems be induction asparaginase urease expression. also demonstrated lack negatively affected synthesis phthiocerol dimycocerosates. This finding consistent with lipid anabolism maintaining redox stress mycobacteria. Altogether results study indicate plays an important response mechanisms bovis.